Load Balancing Scheduling Algorithm for Concurrent Workflow

Concurrent workflow scheduling algorithm works in three phases, namely rank computation, tasks selection, and resource selection. In this paper, we introduce a new ranking algorithm that computes the rank of a task, based on its successor rank and its predecessors average communication time, instead of its successors rank. The advantage of this ranking algorithm is that two dependent tasks are assigned to the same machine and as a result the scheduled length is reduced. The task selection phase selects a ready task from each workflow and creates a task pool. The resource selection phase initially assigns tasks using min-min heuristic, after initial assignment, tasks are moved from the highly loaded machines to the lightly loaded machines. Our resource selection algorithm increases the load balance among the resources due to tasks assignment heuristic and reassignment of tasks from the highly loaded machines. The simulation results show that our proposed scheduling algorithm performs better over existing approaches in terms of load balance, makespan and turnaround time

One-pot solvent-free rapid and green synthesis of 3,4-dihydropyrano[c]chromenes using grindstone chemistry

An easy solvent-free method is described for the synthesis of 3,4-dihydropyrano[c]chromenes by a one pot three component coupling reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using basic ionic liquid as the catalyst by grindstone chemistry. The salient features of this one pot protocol are short reaction times, cleaner reaction profiles and simple workup

Independent Predictors of Mortality in COVID-19 Myocardial Injury: The Role of Troponin Levels, GRACE Score, SOFA Score, and TIMI Score.

Background Coronavirus disease 2019 (COVID-19) infection is associated with troponin elevation, which is associated with increased mortality. However, it is not clear if troponin elevation is independently linked to increased mortality in COVID-19 patients. Although there is considerable literature on risk factors for mortality in COVID-19-associated myocardial injury, the Global Registry of Acute Coronary Events (GRACE), Thrombolysis in Myocardial Infarction (TIMI), and Sequential Organ Failure Assessment (SOFA) scores have not been studied in COVID-19-related myocardial injury. This data is important in risk-stratifying COVID-19 myocardial injury patients. Methodology Of the 1,500 COVID-19 patients admitted to our hospitals, 217 patients who had troponin levels measured were included. Key variables were collected manually, and univariate and multivariate cox regression analysis was done to determine the predictors of mortality in COVID-19-associated myocardial injury. The differences in clinical profiles and outcomes of COVID-19 patients with and without troponin elevation were compared. Results Mortality was 26.5% in the normal troponin group and 54.6% in the elevated troponin group. Patients with elevated troponins had increased frequency of hypotension (p = 0.01), oxygen support (p \u3c 0.01), low absolute lymphocyte (p \u3c 0.01), elevated blood urea nitrogen (p \u3c 0.01), higher C-reactive protein (p \u3c 0.01), higher D-dimer (p \u3c 0.01), higher lactic acid (p \u3c 0.01), and higher Quick SOFA (qSOFA), SOFA, TIMI, and GRACE (all scores p \u3c 0.01). On univariate cox regression, troponin elevation (hazard ratio (HR) = 1.85, 95% confidence interval (CI) = 1.18-2.88, p \u3c 0.01), TIMI score \u3e3 (HRv = 1.79, 95% CI = 1.11-2.75, p = 0.01), and GRACE score \u3e140 (HR = 2.27, 95% CI = 1.45-3.55, p \u3c 0.01) were highly associated with mortality, whereas cardiovascular disease (HR = 1.40, 95% CI = 0.89-2.21, p = 0.129) and cardiovascular risk factors (HR = 1.15, 95% CI = 0.73-1.81, p = 0.52) were not. After adjusting for age, use of a non-rebreather or high-flow nasal cannula, hemoglobi